Angioedema is the swelling of themucosal membranes as a variant of urticaria induced by hereditary C1 esterase inhibitor enzyme\ndeficiency, certain foods, or drugs. Herein, we report the case of a 23-year-old woman, with mild-moderate acne presenting\nwith widespread facial angioedema on the 2nd day of systemic isotretinoin treatment. The patient had taken no drugs other\nthan isotretinoin in the preceding days and had no known food allergy. Her angioedema was resolved after the isotretinoin was\ndiscontinued.We want to draw the attention of dermatologists to this rare adverse allergic effect of isotretinoin which is frequently\nused in the treatment of acne vulgaris.
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